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Δ9-tetrahydrocannabinol on human breast cancer :

It has been recently shown that cannabinoids, the active components of marijuana and their derivatives, inhibit cell cycle progression of human breast cancer cells. Here we studied the mechanism of Δ9-tetrahydrocannabinol (THC) antiproliferative action in these cells, and show that it involves the modulation of JunD, a member of the AP-1 transcription factor family.

THC activates JunD both by upregulating gene expression and by translocating the protein to the nuclear compartment, and these events are ...

1.0 Introduction #

Cannabis sativa is one of the most widely used psychoactives and has a documented history of use going back thousands of years; however, the mechanisms of its actions are only just being elucidated. Until relatively recently, the intoxicating effect of cannabis was thought to act in a way similar to ethanol. The active principle, Δ9-tetrahydrocannabinol (THC), a highly lipophilic molecule, was thought to insert itself into the lipid cell membrane of nerve ...

This is a great medical cannabis article,

My dearest friend was diagnosed with Chron’s two years ago, although her symptoms were present for the last ten years. I have watched her go through an incredible variety of health problems – intense abdominal pain, swollen limbs, nerves bulging out of her neck and arms. These are just some of the symptoms she has had to endure. She takes 8 vicodins ...

Grizz

Diabetic Neuropathy

Grizz has learned a few things in his 56 years of life. Mostly, he’s learned to take better care of himself than he did in his rough and reckless youth. Grizz spent a huge share of his life riding the rails across America—stowaway freight on speeding locomotives—a vagabond hobo, dead-drunk and howling at the moon, bouncing along on an endless chain of bumpy trains, thrumming through the night—clackity-clackity-clackity-clack. ...

There have been a number of major scientific breakthroughs regarding cannabis and it’s effect on health and well being in the last decade. Long regarded as a folk medicine with major beneficial and curative pow
ers, cannabis has been the focus of eight decades of prohibition. However, recent laws are beginning to change that. Seventeen states, along with the District of Columbia have enacted Medical Cannabis or Medicinal Marijuana ...

This headline popped out at me the other day…“While self-medicating with cannabinoids may provide some pain relief to fibromyalgia patients, we caution against general use of illicit drugs;“ the journal of Arthritis Care & Research. As a general rule of thumb, I tend to take those types of warnings with a grain of salt. Instead – my primary thought process headed in another direction. Rather than warning the already supportive masses, against a plant ...

Smoked Medical Cannabis May Be Beneficial as , Study Suggests

ScienceDaily (Aug. 30, 2010) — The medicinal use of cannabis has been debated by clinicians, researchers, legislators and the public at large for many years as an alternative to standard pharmaceutical treatments for pain, which may not always be effective and may have unwanted side effects. A new study by McGill University Health Centre (MUHC) and McGill University researchers provides evidence that cannabis may offer ...

The amazing cannabis plant, & how it grows

PHOTOPERIOD AND FLOWERING

For the cannabis grower the most important plant/environment interaction to understand is the influence of the photoperiod. The photoperiod is the daily number of hours of day (light) vs. night (dark). In nature, long nights signal the plant that winter is coming and that it is time to flowers and produce seeds. As long as the day-length is ...

For thousands of years humans have lived with the cannabis plant, using it for food, fuel, clothing, medicine, and inspiration. However, only recently has anyone begun exclusively using pot by-products as their sole artistic medium.
His name is Forest Ray. He’s a lifelong Pacific Northwest artist who creates his art completely out of cannabis derived materials: the paper is produced from hemp, the “ink” from resin, and the “charcoal” from ash.

Most recently, Ray ...

Oxford Study Shows Caryophyllene (terpene) as a Dietary Cannabinoid

What does this mean? Cannabis ususally contains a significant amount of a terpene called beta-caryophyllene (BCP), which contributes to the aroma and flavor of cannabis. The study shows that this terpene, also found in other legal herbs, spices and food plants, activates the CB2 receptor and acts as a non-psychoactive anti-inflammatory. Because it binds to a cannabinoid receptor, it is considered a cannabinoid. WOW!

Question: Does non-psychoactive ...